diff --git a/src/citra_qt/configuration/configure_enhancements.cpp b/src/citra_qt/configuration/configure_enhancements.cpp
index 3619adb34..0914d37f4 100644
--- a/src/citra_qt/configuration/configure_enhancements.cpp
+++ b/src/citra_qt/configuration/configure_enhancements.cpp
@@ -42,6 +42,8 @@ ConfigureEnhancements::ConfigureEnhancements(QWidget* parent)
         if (!ui->toggle_preload_textures->isEnabled())
             ui->toggle_preload_textures->setChecked(false);
     });
+
+    ui->toggle_disk_shader_cache->setEnabled(Settings::values.use_hw_shader);
 }
 
 void ConfigureEnhancements::SetConfiguration() {
@@ -52,7 +54,8 @@ void ConfigureEnhancements::SetConfiguration() {
     ui->toggle_linear_filter->setChecked(Settings::values.filter_mode);
     ui->layout_combobox->setCurrentIndex(static_cast<int>(Settings::values.layout_option));
     ui->swap_screen->setChecked(Settings::values.swap_screen);
-    ui->toggle_disk_shader_cache->setChecked(Settings::values.use_disk_shader_cache);
+    ui->toggle_disk_shader_cache->setChecked(Settings::values.use_hw_shader &&
+                                             Settings::values.use_disk_shader_cache);
     ui->upright_screen->setChecked(Settings::values.upright_screen);
     ui->toggle_dump_textures->setChecked(Settings::values.dump_textures);
     ui->toggle_custom_textures->setChecked(Settings::values.custom_textures);
@@ -101,7 +104,8 @@ void ConfigureEnhancements::ApplyConfiguration() {
     Settings::values.layout_option =
         static_cast<Settings::LayoutOption>(ui->layout_combobox->currentIndex());
     Settings::values.swap_screen = ui->swap_screen->isChecked();
-    Settings::values.use_disk_shader_cache = ui->toggle_disk_shader_cache->isChecked();
+    Settings::values.use_disk_shader_cache =
+        Settings::values.use_hw_shader && ui->toggle_disk_shader_cache->isChecked();
     Settings::values.upright_screen = ui->upright_screen->isChecked();
     Settings::values.dump_textures = ui->toggle_dump_textures->isChecked();
     Settings::values.custom_textures = ui->toggle_custom_textures->isChecked();
diff --git a/src/video_core/renderer_opengl/gl_shader_disk_cache.cpp b/src/video_core/renderer_opengl/gl_shader_disk_cache.cpp
index 1e8ca1041..d73b85db4 100644
--- a/src/video_core/renderer_opengl/gl_shader_disk_cache.cpp
+++ b/src/video_core/renderer_opengl/gl_shader_disk_cache.cpp
@@ -106,7 +106,7 @@ ShaderDiskCache::ShaderDiskCache(bool separable) : separable{separable} {}
 
 std::optional<std::vector<ShaderDiskCacheRaw>> ShaderDiskCache::LoadTransferable() {
     const bool has_title_id = GetProgramID() != 0;
-    if (!Settings::values.use_disk_shader_cache || !has_title_id)
+    if (!Settings::values.use_hw_shader || !Settings::values.use_disk_shader_cache || !has_title_id)
         return {};
     tried_to_load = true;